陈晓军,副教授,医学博士,硕士生导师
科学研究方向 病原体感染与致病
通讯:江苏省南京市江宁区龙眠大道101号学海楼,邮编211166
电话:15105145707
传真:
电邮:chenxiaojun@njmu.edu.cn
简介
本人一直从事病原体感染与致病的机制研究,聚焦于巨噬细胞诱导CD4+ T 细胞分化为不同的亚群在病原体致病中所起的关键作用及调控机制。主持国家自然科学基金面上项目、国家自然科学基金青年基金、江苏省自然科学基金优秀青年基金、江苏省自然科学基金青年基金等项目。
教育背景及工作经历
2018-至今 学院 金沙威尼斯欢乐娱人城 病原生物学系 副教授
2014-2018 学院 金沙威尼斯欢乐娱人城 病原生物学系 讲师
2008-2014 学院 病原生物学 医学博士
2004-2008 学院 药学 理学学士
奖项及荣誉
1. 2020年学院恒瑞教学团队奖教金,金沙威尼斯欢乐娱人城形态实验学团队,主要参与人。
2. 2018年全国大学生创业大赛第十一届“挑战杯”大学生创业大赛计划竞赛银奖,指导教师。
3. 2018“创青春”江苏省大学生创业大赛金奖,第一指导教师。
4. 获得第五批学院“优秀中青年教师支持计划”。
5. 2015年度学院优秀博士毕业论文获得者。
学术兼职
中国免疫学会青年工作委员会:委员;
江苏省免疫学会理事会:理事;
江苏省免疫学会科普工作委员会:副主任委员;
江苏省免疫学会青年工作委员会:常务委员、秘书长;
江苏省免疫学会转化医学专业委员会:常务委员;
中国寄生虫学与寄生虫病杂志、中国热带医学杂志和Zoonoses杂志:青年编委;
Frontiers in Immunology: 编委;
Journal of Immunology Research和Frontiers in Cellular and Infection Microbiology杂志的 Guest Editor。
承担科研课题
1. 国家自然科学基金面上项目,核因子κB受体活化因子配体介导的信号导致日本血吸虫感染小鼠胸腺萎缩进而引起免疫抑制的机制研究,2019/01-2022/12,57万元,在研,项目负责人。
2. 江苏省自然科学基金优秀青年基金项目,胰岛素样生长因子-1通过维持肝内ST2+Treg细胞表型进而调控肝纤维化形成的机制研究,2019/07-2022/06,50万元,在研,项目负责人。
3. 国家自然科学基金青年科学基金项目,滤泡辅助性T细胞通过趋化嗜酸性粒细胞来促进血吸虫性肝病发生发展的机制研究,2016/01-2018/12,18万元,结题,项目负责人。
4. 江苏省自然科学基金青年基金项目,滤泡辅助性T 细胞促进血吸虫性肝病形成的机制研究,2015/07-2018/06,20万元,结题,项目负责人。
1. Wei Li, Chuan Wei, Lei Xu, Beibei Yu, Ying Chen, Di Lu, Lina Zhang, Xian Song, Liyang Dong, Sha Zhou, Zhipeng Xu, Jifeng Zhu, Xiaojun Chen*, Chuan Su*. Schistosome infection promotes osteoclast-mediated bone loss. PLOS Pathogens 2021, 17(3):e1009462.
2. Xiaojun Chen#, Kai Li#, Lei Xu#, You-jia Yu#, Bo Wu#, Yuan-lin He#, Wen-e Zhao, Ding Li, Chang-xing Luan, Li Hu, Jie Wang, Jing-jing Ding, Yan-fang Yu, Jing-Xin Li8, Zhong-ming Tan, Xiao-fei Liu, Dong Wei, Zhi-hong Zhang, Xue-jiang Guo, Chuan Su, Zhi-bin Hu, Yue-shuai Guo*, Jing-yu Chen*, Feng Chen*. Novel insight from the first lung transplant of a COVID-19 patient. European Journal of Clinical Investigation 2021, 51(1): e13443.
3. Yongbin Ma, Chuan Wei, Xin Qi, Yanan Pu, Liyang Dong, Lei Xu, Sha Zhou, Jifeng Zhu, Xiaojun Chen*, Xuefeng Wang*, Chuan Su*. Schistosoma japonicum-derived peptide SJMHE1 promotes peripheral nerve repair through a macrophage-dependent mechanism. American journal of translational research 2021, 13(3): 1290-1306.
4. Liyang Dong#, Yanan Pu#, Xiaojun Chen#, Xin Qi, Lina Zhang, Lei Xu, Wei Li, Yongbin Ma, Sha Zhou, Jifeng Zhu, Yalin Li, Xuefeng Wang, Chuan Su*. hUCMSC-extracellular vesicles downregulated hepatic stellate cell activation and reduced liver injury in S. japonicum-infected mice. Stem Cell Research & Therapy 2020, 11: 21.
5. Chuan Wei#, Ying Chen#, Lei Xu#, Beibei Yu, Di Lu, Yanxiong Yu, Zhigang Lei, Rui Tang, Sha Zhou, Jifeng Zhu, Xiaojun Chen*, Chuan Su*. CD40 Signaling Promotes CXCR5 Expression in B Cells via Noncanonical NF-κB Pathway Activation. Journal of Immunology Research 2020: 1859260.
6. Xiaojun Chen#, Zhipeng Xu#, Chuan Wei, Xiaowei Yang, Lei Xu, Sha Zhou, Jifeng Zhu, Chuan Su*. Follicular helper T cells recruit eosinophils into host liver by producing CXCL12 during Schistosoma japonicum infection. Journal of Cellular Molecular Medicine 2020, 24: 2566-2572.
7. Lei He#, Sha Zhou#, Qianqian Qi, Ying Chi, Jifeng Zhu, Zhipeng Xu, Xuefeng Wang, Hoellwarth J, Feng Liu, Xiaojun Chen*, Chuan Su*. The regulation of regulation: interleukin-10 increases CD4(+) CD25(+) regulatory T cells but impairs their immunosuppressive activity in murine models with schistosomiasis japonica or asthma. Immunology 2018, 153(1): 84-96.
8. Liyang Dong, Yanan Pu, Qianqian Qi, Lei Xu, Lina Zhang, Wei Li, Chuan Wei, Xiaofan Wang, Sha Zhou, Jifeng Zhu, Xuefeng Wang, Feng Liu, Xiaojun Chen*, Chuan Su*. Human umbilical cord mesenchymal stem cell-derived extracellular vesicles promote lung adenocarcinoma growth by transferring miR-410. Cell Death & Disease 2018. 9: 218.
9. Lei Xu#, Wei Li#, Xiaofan Wang, Lina Zhang, Qianqian Qi, Liyang Dong, Chuan Wei, Yanan Pu, Yalin Li, Jifeng Zhu, Sha Zhou, Feng Liu, Xiaojun Chen*, Chuan Su*. The IL-33-ST2-MyD88 axis promotes regulatory T cell proliferation in the murine liver. European Journal of Immunology 2018. 48: 1302–1307.
10. Sha Zhou, Qianqian Qi, Xiaofan Wang, Lina Zhang, Lei Xu, Liyang Dong, Jifeng Zhu, Yalin Li, Xuefeng Wang, Zhipeng Xu, Feng Liu, Wei Hu, Liang Zhou, Xiaojun Chen*, Chuan Su*. SjHSP60 induces CD4(+) CD25(+) Foxp3(+) Tregs via TLR4-Mal-drived production of TGF-beta in macrophages. Immunology & Cell Biology 2018, 96(9):958-968.
11. Zhipeng Xu, Lei Xu, Wei Li, Xin Jin, Xian Song, Xiaojun Chen*, Jifeng Zhu, Sha Zhou, Yong Li, Weiwei Zhang, Xiaoxiao Dong, Xiaowei Yang, Feng Liu, Hui Bai, Qi Chen, Chuan Su*. Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection. Nature Communications 2017, 8:16035.
12. Xiaojun Chen, Wei Li, Yalin Li, Lei Xu, Sha Zhou, Jifeng Zhu, Zhipeng Xu*, Feng Liu, Dandan Lin, Fei Hu, Yuemin Liu, Wen Jiang, Liwang Cui, Chuan Su*. Elevated serum antibody against Schistosoma japonicum HSP60 as a promising biomarker for liver pathology in schistosomiasis. Scientific Reports 2017, 7(1):7765.
13. Xiaojun Chen, Wei Li, Yang Zhang, Xian Song, Lei Xu, Zhipeng Xu, Sha Zhou, Jifeng Zhu, Xin Jin, Feng Liu, Gengxin Chen, Chuan Su*. Distribution of Peripheral Memory T Follicular Helper Cells in Patients with Schistosomiasis Japonica. PLOS Neglected Tropical Diseases 2015, 9(8):e0004015.
14. Xiaojun Chen, Xiaowei Yang, Yong Li, Jifeng Zhu, Sha Zhou, Zhipeng Xu, Lei He, Xue Xue, Weiwei Zhang, Xiaoxiao Dong, Henry Wu, Carrie J Li, Hsiang-Ting Hsu, Wenjun Kong, Feng Liu, Prem B. Tripathi, Michelle S. Yu, Jason Chang, Liang Zhou, Chuan Su*. Follicular helper T cells promote liver pathology in mice during Schistosoma japonicum infection. PLOS Pathogens 2014, 10(5):e1004097.
15. 发明人:苏川、陈晓军、周莎,中国发明专利,SjHSP60在制备监测血吸虫病患者综合肝脏病理损伤程度的诊断试剂中的应用,专利授权号:ZL201210556695.2,授权时间:2014年。