杨芬，副教授，医学博士
科学研究方向：RNA修饰/LncRNA与肿瘤表观调控
联系方式：
通讯：江苏省南京市江宁区龙眠大道101号学海楼，邮编211166
电邮：yangfen@njmu.edu.cn
简介
2012年毕业于中山大学肿瘤防治中心（华南肿瘤学国家重点实验室），获肿瘤学博士学位，同年9月进入南京医科大学金沙威尼斯欢乐娱人城工作。主要研究方向为RNA修饰与肿瘤表观调控的分子机制，先后主持国家自然科学基金青年项目、面上项目和江苏省自然科学基金面上项目，发表科研论文30余篇，其中以第一作者或通讯作者在Nature Communication, Molecular Cancer, Cell Death & Disease，Cell Death & Discovery和Life Sciences等国际知名期刊发表科研论文10余篇，发表教学论文4篇，参编教材2部。
工作经历
2019-至今 学院生物化学与分子生物学系 副教授
2019-2021 美国德州大学MD安德森肿瘤中心 Research Scientist
2012-2019 学院生物化学与分子生物学系讲师
奖项及荣誉
2016年学院青年教师讲课比赛二等奖和最佳教案奖
2016年全国高校医学类微课教学比赛三等奖
2019年全国高校医学类微课教学比赛三等奖
学术兼职
江苏省细胞发育学会会员
中国抗癌协会会员
主持科研项目
1. 国家自然科学基金-面上项目，32270649，m6A阅读蛋白SF3B4调控MAT2A可变剪接促进肝癌发生的机制研究，2023/1-2016/12, 54万元，在研，主持。
2. 江苏省自然科学基金-面上项目，BK20181365，血小板外泌体源性lncRNA LINC00355促进胃癌转移的分子机制研究，2018/7-2021/6，10万元，已结题，主持。
3. 国家自然科学基金-青年项目，31401094，长链非编码RNA ANRIL下调PLZF表达介导胃癌细胞上皮-间充质转化的机制研究，2015/1-2017/12，26万元，已结题，主持。
代表性论文(#第一作者， *通讯作者)：
1. Wenjing Zhao#, Yunan Zhang, Wei Zhang, Yiming Sun, Beiyao Zheng, Junbin Wang, Yazhou Gu, Junxia, Qi, Juxue, Li, Xuejun Wang*, Jinfei Chen* and Fen Yang*. Exosomal LINC00355 promotes the malignant progression of gastric cancer through histone deacetylase HDAC3-mediated TP53INP1 transcriptional inhibition. Life Sciences. 2023, In press.
2. Fen Yang#, Jianji Chen, Bin Liu, Guozhen Gao, Manu Sebastian, Collene Jeter, Jianjun Shen, Maria D Person and Mark T Bedford*. SPINDOC binds PARP1 to facilitate PARylation. Nature Communications. 2021;12(1):6362.
3. Wenjing Zhao#, Yan Jin, Peng Wu, Jian Yang, Yuanyuan Chen, Qianlu Yang, Xinying Huo, Juxue Li, Wei De, Jinfei Chen* and Fen Yang*. LINC00355 induces gastric cancer proliferation and invasion through promoting ubiquitination of P53. Cell Death Discovery. 2020;6:99.
4. Jun-Bin Wang# , Yan Jin#, Peng Wu, Yang Liu, Wen-Jing Zhao, Jin-Fei Chen, Wei De
and Fen Yang*.Methylation of tumor suppressor PLZF by long noncoding RNA
ANRIL suppresses proliferation and epithelial mesenchymal transformation of gastric
cancer cells. Oncology Reports, 2019;41(2):1007-1018.
5. Jin-Fei Chen#, Peng Wu#, Rui Xia, Jian Yang, Xin-Ying Huo, Dong-Ying Gu, Cui-Ju Tang, Wei De and Fen Yang*. STAT3-induced lncRNA HAGLROS overexpression contributes to the malignant progression of gastric cancer cells via mTOR signal-mediated inhibition of autophagy. Molecular cancer, 2018;17(1):6.
6. Yan Jin#, Peng Wu#, Wen-Jing Zhao, Xuejun Wang, Jian Yang, Xin-Ying Huo, Jin-Fei Chen, Wei De and Fen Yang*. Long noncoding RNALINC00165-induced by STAT3 exerts oncogenic properties via interaction with Polycomb Repressive Complex 2 to promote EMT in gastric cancer. Biochemical and Biophysical Research Communications, 2018;507(1-4):223-230.
7. Fen Yang#, Rong Deng#, Xiaojun Qian#, Shaohua Chang, Xiaoqi Wu, Juan Qin, Gongkan Feng, Ke Ding* and Xiaofeng Zhu*. Feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel AKT inhibitor DC120 in human liver cancer. Cell Death & Disease, 2014; 5:e1114.
8. Fen Yang#, Xiaojun Qian#, Wei Qin#, Rong Deng, Juan Qin, Gongkan Feng, Xiaofeng Zhu*. Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 has a therapeutic potential and sensitizes cisplatin in nasopharyngeal carcinoma. PLOS One, 2013;8(3):e59879.
9. Rong Deng#, Fen Yang#, Shao-hua Chang, Jun Tang, Gong-Kan Feng, Juan Qin, Ke Ding and Xiao-Feng Zhu*. DC120, a novel and potent inhibitor of AKT kinase, induces tumor cells apoptosis and suppresses tumor growth. Molecular Pharmacology, 2012;82(2):189-198.
10. Wei Qin#, Fen Yang#, Rong Deng, Dandan Li, Zhi Song, Yaguang Tian, Runfu Wang, Junqi Ling, Zhengmei Lin*, Smad 1/5 is involved in bone morphogenetic protein-2–induced odontoblastic differentiation in human dental pulp cells. Journal of Endodontics2012; 38(1):66-71.
